MAPK12 蛋白
Quick Overview for MAPK12 蛋白 (ABIN7317045)
抗原
See all MAPK12 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human ERK3/MAPK12 Protein
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序列
- Met 1-Leu 367
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产品特性
- A DNA sequence encoding the human MAPK12 (P53778) (Met1-Leu367) was fused with two additional amino acids (Gly & Pro) at the N-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 106,314.67 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 152,621.24 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (His tag)
custom-made MAPK12 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (His tag)custom-made MAPK12 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (His-IF2DI Tag)MAPK12 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (GST tag)MAPK12 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA, KAA
Mitogen-Activated Protein Kinase 12 (MAPK12) protein (GST tag,His tag)MAPK12 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (His tag)MAPK12 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS
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限制
- 仅限研究用
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状态
- Frozen, Liquid
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缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- MAPK12 (Mitogen-Activated Protein Kinase 12 (MAPK12))
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别名
- ERK3/MAPK12
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背景
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Background: ERK3; also known as MAPK12 and p38-gamma; belongs to the protein kinase superfamily; CMGC Ser/Thr protein kinase family and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly; p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1; prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
Synonym: ERK-6;ERK3;ERK6;MAPK12;P38GAMMA;PRKM12;SAPK-3;SAPK3;P38-gamma
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分子量
- 42.1 kDa
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UniProt
- P53778
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途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C, BCR Signaling, S100 Proteins
抗原
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