MBL2 蛋白
Quick Overview for MBL2 蛋白 (ABIN7196928)
抗原
See all MBL2 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human MBL2/MBL/COLEC1 Protein
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序列
- Met 1-Ile 248
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产品特性
- A DNA sequence encoding the human MBL (NP_000233.1) (Met1-Ile 248) was expressed.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2) protein
MBL2 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2) protein (His tag)MBL2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2) (AA 130-248) (Active) protein (His tag,GST tag)MBL2 宿主: 人 宿主: 大肠杆菌（E. Coli） > 97 % AcA, CC Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- MBL2 (Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2))
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别名
- MBL2/MBL/COLEC1
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背景
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Background: MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.
Synonym: Mannose-Binding Protein C, MBP-C, Collectin-1, MBP1, Mannan-Binding Protein, Mannose-Binding Lectin, MBL2, MBL,COLEC1,HSMBPC,MBL,MBL2D,MBP,MBP1,MBPD
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分子量
- 24 kDa
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NCBI登录号
- NP_000233
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途径
- Complement System, Positive Regulation of Immune Effector Process
抗原
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