LI Cadherin Protein (His tag)
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Quick Overview for LI Cadherin Protein (His tag) (ABIN7321151)
抗原
See all LI Cadherin 蛋白蛋白类型
宿主
资源
纯度
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标记
- This LI Cadherin protein is labelled with His tag.
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原理
- Recombinant Rat Cadherin-17/CDH17 Protein (His Tag)
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序列
- Met1-Met786
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产品特性
- A DNA sequence encoding the rat CDH17 (P55281) (Met1-Met786) was expressed, fused with a polyhistidine tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
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LI Cadherin (AA 23-787) (Active) protein (hFc Tag)
宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
LI Cadherin (AA 23-787) (Active) protein (Biotin,His-Avi Tag)宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
LI Cadherin (AA 1-795) protein (His tag)宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE
LI Cadherin (AA 30-244) (Active) protein (His tag)宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
LI Cadherin (AA 23-667) (Active) protein (His tag)宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
LI Cadherin (AA 567-777) (Active) protein (hFc Tag)宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
LI Cadherin (AA 23-787) (Active) protein (His tag,FITC)宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
LI Cadherin (AA 30-792) protein (His tag)宿主: Cynomolgus 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
LI Cadherin (AA 450-777) (Active) protein (His tag)宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
LI Cadherin (AA 24-131) protein (GST tag)宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- LI Cadherin
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别名
- Cadherin-17/CDH17
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背景
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Background: Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.
Synonym: CDH17
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分子量
- 86.4 kDa
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UniProt
- P55281
抗原
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