LTA4H Protein (His tag)
Quick Overview for LTA4H Protein (His tag) (ABIN7320340)
抗原
See all LTA4H 蛋白蛋白类型
生物活性
宿主
资源
纯度
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标记
- This LTA4H protein is labelled with His tag.
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原理
- Recombinant Mouse LTA4H Protein (His Tag)(Active)
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序列
- Met 1-Asp 611
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产品特性
- A DNA sequence encoding the mouse LTA4H (NP_032543.2) (Met 1-Asp 611) was expressed, with a C-terminal polyhistidine tag.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Measured by its ability to cleave the fluorogenic peptide substrate, Arg-7-amido-4-methylcoumarin (R-AMC). The specific activity is >15 pmoles/min/μg.
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Leukotriene A4 Hydrolase (LTA4H) (AA 1-611) protein (GST tag)
LTA4H 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Leukotriene A4 Hydrolase (LTA4H) protein (Myc-DYKDDDDK Tag)LTA4H 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- LTA4H (Leukotriene A4 Hydrolase (LTA4H))
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别名
- LTA4H
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背景
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Background: Leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H and LTA4, is cytoplasm protein which belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may in turn be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.
Synonym: Lta4h
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分子量
- 70.4 kDa
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NCBI登录号
- NP_032543
抗原
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