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Quick Overview for IL-22 蛋白 (ABIN7320589)
抗原
See all IL-22 (IL22) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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原理
- Recombinant Mouse Interleukin-22/IL-22 Protein (Active)
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序列
- Leu34-Val179
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产品特性
- Recombinant Mouse Interleukin-22 is produced by our E.coli expression system and the target gene encoding Leu34-Val179 is expressed.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is 281.45 pg/mL.
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Interleukin 22 (IL22) (AA 34-179) protein (His tag)
IL22 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 22 (IL22) (AA 34-179) protein (His tag)IL22 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 22 (IL22) (AA 34-179) protein (His-Avi Tag,Biotin)IL22 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Interleukin 22 (IL22) (AA 34-179) (Active) protein (His tag,AVI tag,Biotin)IL22 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 22 (IL22) protein (mFc Tag)IL22 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Interleukin 22 (IL22) (AA 27-172) protein (His tag)IL22 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 22 (IL22) (AA 1-179) protein (GST tag)IL22 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 22 (IL22) (AA 34-179) (Active) protein (His tag)IL22 宿主: 人 宿主: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, ELISA, Imm, AcA Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.0.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- IL-22 (IL22) (Interleukin 22 (IL22))
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别名
- Interleukin-22/IL-22
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背景
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Background: Interleukin-22 (IL-22) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid residue protein with a putative 33 amino acid signal peptide that is cleaved to generate a 147 amino acid mature protein that shares approximately 79 % and 22 % sequence identity with human IL22 and IL10, respectively. IL22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and up-regulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10Rβ (previously known as CRF2-4), belonging to the class II cytokine receptor family.
Synonym: Interleukin-22, IL-22, IL-10-Related T-Cell-Derived-Inducible Factor, IL-TIF, IL-TIF Alpha, Interleukin-22a, IL-22a, Il22, Il22a, Iltif, Iltifa
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分子量
- 16.7 kDa
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UniProt
- Q9JJY9
抗原
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