IL36A/IL1F6 Protein (AA 8-160)
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北京 101111
Quick Overview for IL36A/IL1F6 Protein (AA 8-160) (ABIN7320595)
抗原
See all IL36A/IL1F6 (IL1F6) 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 8-160
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原理
- Recombinant Mouse IL1F6/IL36A Protein
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序列
- Arg8-His160
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产品特性
- Recombinant Mouse Interleukin-36 alpha is produced by our E.coli expression system and the target gene encoding Arg8-His160 is expressed.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Interleukin 1 Family, Member 6 (IL1F6) (AA 6-158) (Active) protein (His tag)
IL1F6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 98 % as determined by reducing SDS-PAGE. CC Active
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-158) protein (GST tag)IL1F6 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Interleukin 1 Family, Member 6 (IL1F6) (AA 8-160) (Active) proteinIL1F6 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >90 % as determined by SDS-PAGE. WB, ELISA, SDS, Imm, AcA Active
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-158) (Active) protein (His tag)IL1F6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >90 % as determined by SDS-PAGE. WB, ELISA, SDS, Imm, AcA Active
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-160) protein (His-IF2DI Tag)IL1F6 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-158) protein (His tag)IL1F6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))
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别名
- IL1F6/IL36A
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背景
- Interleukin-1 homolog,nterleukin-1 family member,Il1f,Il1h,IL-1F,IL-1H,FIL1 epsilon,FISP,IL-1 epsilon,IL-1F6,IL-1H1,Interleukin-1 epsilon,Interleukin-1 homolog 1,Interleukin-36 alpha,MDA-7 (Melanoma Differentiation-Associated gene 7 protein),nterleukin-1 family member 6,St16,Fil1e,Il1e,Il1f6,Il1h1,Il36a,Interleukin-36 alpha(Il-36a) is a member of the IL-1 family. IL36a is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. It is a part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor IL1RAP. It seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Moreover, it is involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and can induce the production of IFN-gamma, IL-4 and IL-17 by cultured CD4+ T cells and splenocytes. Il36a may play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c+ alveolar macrophages. It may be involved in T cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c+ cells and CD4+ T cell proliferation.
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分子量
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Calculated MW: 17.3 kDa
Observed MW: 16 kDa
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UniProt
- Q9JLA2
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途径
- Cancer Immune Checkpoints
抗原
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