HDAC4 蛋白
Quick Overview for HDAC4 蛋白 (ABIN7317483)
抗原
See all HDAC4 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human HDAC4 Protein (aa 612-1084)
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序列
- Met612-Leu1084
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产品特性
- A DNA sequence encoding the human HDAC4 (Met612-Leu1084) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 115,504.49 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 172,528.32 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Histone Deacetylase 4 (HDAC4) (AA 1-1076) protein (His tag)
custom-made HDAC4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Histone Deacetylase 4 (HDAC4) (AA 1-1084) protein (His tag)custom-made HDAC4 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Histone Deacetylase 4 (HDAC4) (AA 1-972) protein (GST tag)HDAC4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Histone Deacetylase 4 (HDAC4) (AA 551-648) protein (GST tag)HDAC4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Histone Deacetylase 4 (HDAC4) protein (Myc-DYKDDDDK Tag)HDAC4 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile 20 mM Tris,500 mM NaCl, pH 7.4, 10 % gly
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- HDAC4 (Histone Deacetylase 4 (HDAC4))
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别名
- HDAC4
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背景
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Background: HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/acuc/apha family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs, classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions and by the class to which they belong. HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents. HDAC4 possesses histone deacetylase activity and represses transcription when tethered to a promoter. It does not bind DNA directly, but through transcription factors MEF2C and MEF2D. HDAC4 seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Synonym: AHO3,BDMR,HA6116,HD4,HDAC-4,HDAC-A,HDACA
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分子量
- 50.9 kDa
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NCBI登录号
- NP_006028
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process
抗原
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