HDAC4 Protein (AA 645-1057, Catalytic Domain)
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- 抗原 See all HDAC4 蛋白
- HDAC4 (Histone Deacetylase 4 (HDAC4))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- Catalytic Domain, AA 645-1057
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 应用范围
- Enzyme Activity Assay (EAA)
- 产品特性
- HDAC4 is a Class II histone deacetylase with broad substrate specificity. The catalytic domain corresponding to amino acids 645 - 1057 of HDAC4 (accession number NP_006028.2) was expressed in E. coli with an apparent molecular weight of 45 kDa. An epitope tag present during expression was removed proteolytically after purification.
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- Discover our top product HDAC4 蛋白
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Histone Deacetylase 4 (HDAC4) (AA 1-972) protein (GST tag)
HDAC4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Histone Deacetylase 4 (HDAC4) (AA 551-648) protein (GST tag)HDAC4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Histone Deacetylase 4 (HDAC4) (AA 1-1084) protein (Strep Tag)Crystallography grade HDAC4 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Histone Deacetylase 4 (HDAC4) (AA 1-1076) protein (Strep Tag)Crystallography grade HDAC4 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Histone Deacetylase 4 (HDAC4) protein (Myc-DYKDDDDK Tag)HDAC4 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Histone Deacetylase 4 (HDAC4) (AA 1-227), (partial) protein (GST tag)HDAC4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 应用备注
- Recombinant HDAC4 is suitable for use in histone deacetylase (HDAC) assays. A good starting point is 2 to 5 ng of enzyme per assay.
- 限制
- 仅限研究用
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- 注意事项
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- 储存条件
- -80 °C
- 储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- 抗原
- HDAC4 (Histone Deacetylase 4 (HDAC4))
- 别名
- HDAC4 (HDAC4 产品)
- 别名
- CG1770 Protein, DHDAC4 Protein, Dmel\\CG1770 Protein, GC1770 Protein, HDAC Protein, HDAC4a Protein, dHDAC4 Protein, dmHDA405 Protein, hdac4 Protein, dana_GLEANR_19966 Protein, DanaGF18710 Protein, GF18710 Protein, HDAC4 Protein, AHO3 Protein, BDMR Protein, HA6116 Protein, HD4 Protein, HDAC-4 Protein, HDAC-A Protein, HDACA Protein, 4932408F19Rik Protein, AI047285 Protein, wu:fa96d08 Protein, wu:fc56f08 Protein, zgc:152701 Protein, histone deacetylase 4 Protein, hypothetical protein Protein, Histone deacetylase 4 Protein, GF18710 gene product from transcript GF18710-RC Protein, PTRG_03699 Protein, PGTG_15512 Protein, HDAC4 Protein, Dana\GF18710 Protein, Hdac4 Protein, hdac4 Protein
- 背景
- HDAC4 (Histone Deacetylase 4) is a member of the class IIa mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-ε-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the ε-amino group of a lysine residue. In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, HDAC9 and 10), class III (SIRT1-7) and class IV (HDAC11). Unlike other deacetylases, HDAC4 shuttles between the nucleus and cytoplasm and serves as a nuclear co-repressor that regulates bone and muscle development. HDAC4 interacts with the myocyte enhancer factors Mef2a, Mef2c and Mef2d. It also forms part of a multi-protein complex with RbAp48 and HDAC3. HDAC4 is ubiquitous.
- 分子量
- 45 kDa
- 途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process
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