GZMB Protein (His tag)
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Quick Overview for GZMB Protein (His tag) (ABIN7195987)
抗原
See all GZMB 蛋白蛋白类型
宿主
资源
纯度
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标记
- This GZMB protein is labelled with His tag.
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原理
- Recombinant Human Granzyme B/GZMB Protein (His Tag)
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序列
- Met 1-Tyr 247
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产品特性
- A DNA sequence encoding the proform of human Granzyme B (NP_004122.1) (Met 1-Tyr 247) was expressed with a C-terminal polyhistidine tag.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Granzyme B (GZMB) protein (His tag)
GZMB 宿主: 小鼠 宿主: 人细胞 Recombinant > 85 % as determined by SDS-PAGE
Granzyme B (GZMB) (AA 148-247) protein (GST tag)GZMB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Granzyme B (GZMB) (AA 21-247) protein (GST tag)GZMB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Granzyme B (GZMB) (AA 1-247) protein (GST tag)GZMB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- GZMB (Granzyme B (GZMB))
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别名
- Granzyme B/GZMB
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背景
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Background: Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 30 substrates of GZMB have been identified including the key substrate caspase-3, ICAD and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.
Synonym: CCPI,CGL-1,CGL1,CSP-B,CSPB,CTLA1,CTSGL1,HLP,SECT
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分子量
- 27 kDa
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NCBI登录号
- NP_004122
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途径
- Apoptosis, Caspase Cascade in Apoptosis
抗原
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