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GZMB Protein (His tag)

This Recombinant GZMB protein is expressed in HEK-293 Cells.

产品编号 ABIN7195987

发货至: 中国

Quick Overview for GZMB Protein (His tag) (ABIN7195987)

抗原

See all GZMB 蛋白

GZMB (Granzyme B (GZMB))

蛋白类型

Recombinant

宿主

人

资源

HEK-293 Cells

纯度

> 97 % as determined by reducing SDS-PAGE.

Discover our top product GZMB 蛋白

标记

This GZMB protein is labelled with His tag.

原理

Recombinant Human Granzyme B/GZMB Protein (His Tag)

序列

Met 1-Tyr 247

产品特性

A DNA sequence encoding the proform of human Granzyme B (NP_004122.1) (Met 1-Tyr 247) was expressed with a C-terminal polyhistidine tag.

内毒素水平

< 1.0 EU per μg as determined by the LAL method.
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GZMB 宿主: 大鼠宿主: 大肠杆菌（E. Coli） Recombinant > 97 % SDS, WB, PC, Imm

Granzyme B (GZMB) (AA 21-247) protein (His tag)
GZMB 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS, WB, PC, Imm

Granzyme B (GZMB) (AA 16-244) protein (His tag,GST tag)
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限制

仅限研究用
状态

Lyophilized

溶解方式

Please refer to the printed manual for detailed information.

缓冲液

Lyophilized from sterile PBS, pH 7.4

储存条件

4 °C,-20 °C,-80 °C

储存方法

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
抗原

GZMB (Granzyme B (GZMB))

别名

Granzyme B/GZMB

背景

Background: Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 30 substrates of GZMB have been identified including the key substrate caspase-3, ICAD and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.
Synonym: CCPI,CGL-1,CGL1,CSP-B,CSPB,CTLA1,CTSGL1,HLP,SECT

分子量

27 kDa

NCBI登录号

NP_004122

途径

Apoptosis, Caspase Cascade in Apoptosis

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