Quick Overview for FLT1 Protein (His tag) (ABIN7195819)
抗原
See all FLT1 蛋白蛋白类型
生物活性
宿主
资源
纯度
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标记
- This FLT1 protein is labelled with His tag.
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原理
- Recombinant Rat VEGFR1/FLT-1 Protein (His Tag)(Active)
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序列
- Met1-Glu758
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产品特性
- A DNA sequence encoding the rat FLT1 (P53767) (Met1-Glu758) was expressed with a polyhistidine tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
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Biological Activity Comment
- Measured by its binding ability in a functional ELISA.Immobilized ratFLT1-His at 10 μg/ml (100 μl/well) can bind biotinylated mouse VEGFD-Fc with a linear range of 0.125-2.0 μg/ml.
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Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 27-756) protein (His-Avi Tag)
FLT1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 27-756) protein (His-Avi Tag,Biotin)FLT1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (glycosylated), (Monomer), (Soluble) (Active) proteinFLT1 宿主: 人 宿主: Insect Cells Recombinant > 90 % by SDS-PAGE Active
Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 27-756) protein (His tag)FLT1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 27-756) protein (Fc Tag)FLT1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 23-759) (Active) protein (Fc Tag)FLT1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >85 % as determined by SDS-PAGE. Active
Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 27-756) (Active) protein (His tag,AVI tag,Biotin)FLT1 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 581-687) protein (GST tag)FLT1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
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别名
- VEGFR1/FLT-1
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背景
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Background: Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains seven Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. VEGFR-1 / FLT1 is expressed mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR-1 / FLT1 is not expressed in tumor cell lines. VEGFR-1 / FLT1 is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis. EGF-induced angiogenesis requires inverse regulation of VEGFR-1 and VEGFR-2 in tumor-associated endothelial cells. VEGFR-1 / FLT1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: FLT1;Flt-1;Vegfr1
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分子量
- 84 kDa
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UniProt
- P53767
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途径
- RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
抗原
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