EPH Receptor A7 Protein (EPHA7) (AA 579-998) (His-GST)
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Quick Overview for EPH Receptor A7 Protein (EPHA7) (AA 579-998) (His-GST) (ABIN7317067)
抗原
See all EPH Receptor A7 (EPHA7) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 579-998
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标记
- This EPH Receptor A7 protein is labelled with His-GST.
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原理
- Recombinant Human EphA7/EHK3 Protein (His & GST Tag)
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序列
- Gly579-Val998
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产品特性
- A DNA sequence encoding the human EPHA7 (NP_004431) (Gly579-Val998) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 9.5 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
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EPH Receptor A7 (EPHA7) (AA 1-279) protein (GST tag)
EPHA7 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor A7 (EPHA7) (Active) protein (His tag)EPHA7 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by reducing SDS-PAGE. ELISA Active
EPH Receptor A7 (EPHA7) (AA 1-539) (Active) protein (His tag)EPHA7 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. ELISA Active
EPH Receptor A7 (EPHA7) (AA 1-539) (Active) protein (Fc Tag)EPHA7 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE. ELISA Active
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- EPH Receptor A7 (EPHA7)
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别名
- EphA7/EHK3
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背景
- EHK-3,EHK3,EK11,EPH Homology Kinase 3,EPH-Like Kinase 11,EPHA7,Ephrin Type-A Receptor 7,HEK11,hEK11,Ephrin type-A receptor 7, also known as EphA7, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Eph receptor-mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. The expression of EphA7 was reduced in all tested gastric cancer cell lines, however, there is marked variability in expression among gastric carcinoma specimens. EphA7 may have roles in the pathogenesis and development of gastric carcinomas.
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分子量
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Calculated MW: 75.2 kDa
Observed MW: 76 kDa
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基因ID
- 2045
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NCBI登录号
- NP_004431
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UniProt
- Q15375
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途径
- RTK signaling
抗原
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