ERN1 蛋白
Quick Overview for ERN1 蛋白 (ABIN7317465)
抗原
See all ERN1 蛋白蛋白类型
生物活性
宿主
资源
纯度
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原理
- Recombinant Human ERN1/IRE1 Protein (aa 465-977)(Active)
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序列
- Pro 465-Leu 977
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产品特性
- A DNA sequence encoding the human ERN1 (O75460-1) (Pro 465-Leu 977) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- 1.Kinase activity untested 2. Measured by its nuclease activity to cleave Xbp1 single stem-loop mini-substrate.
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Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 401-500) protein (GST tag)
ERN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 1-70) protein (GST tag)ERN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 465-977) (Active) protein (GST tag,His tag)ERN1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 80 % as determined by reducing SDS-PAGE. Active
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) protein (Myc-DYKDDDDK Tag)ERN1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
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别名
- ERN1/IRE1
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背景
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Background: Trypsin-3; also known as Trypsin III; brain trypsinogen; Serine protease 3 and PRSS3; is a secreted protein which belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression; which is correlated with promoter hypermethylation; in esophageal squamous cell carcinoma and gastric adenocarcinoma.
Synonym: hIRE1p;IRE1;IRE1a;IRE1P
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分子量
- 58.3 kDa
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途径
- ER-Nucleus Signaling, Unfolded Protein Response
抗原
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