DAP Kinase 1 Protein (AA 1-363) (GST tag,His tag)
Quick Overview for DAP Kinase 1 Protein (AA 1-363) (GST tag,His tag) (ABIN7317057)
抗原
See all DAP Kinase 1 (DAPK1) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 1-363
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标记
- This DAP Kinase 1 protein is labelled with GST tag,His tag.
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原理
- Recombinant Human DAPK1/DAP Kinase 1 Protein (aa 1-363, His & GST Tag)(Active)
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序列
- Met 1-Leu 363
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产品特性
- A DNA sequence encoding the N-terminal segment of human DAPK1 (P53355-1) (Met 1-Leu 363) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 20 nmol/min/mg using synthetic R11-S6-Peptide (R11-IAKRRRLSSLRASTSKSESSQK) as substrate.
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 106,314.67 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 172,528.32 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Death-Associated Protein Kinase 1 (DAPK1) (AA 1-1442) protein (His tag)
custom-made DAPK1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Death-Associated Protein Kinase 1 (DAPK1) (AA 1-1430) protein (His tag)custom-made DAPK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Death-Associated Protein Kinase 1 (DAPK1) (AA 1211-1310) protein (GST tag)DAPK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Death-Associated Protein Kinase 1 (DAPK1) (AA 1-368) protein (GST tag)DAPK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Death-Associated Protein Kinase 1 (DAPK1) protein (Myc-DYKDDDDK Tag)DAPK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Frozen, Liquid
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缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- DAP Kinase 1 (DAPK1) (Death-Associated Protein Kinase 1 (DAPK1))
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别名
- DAPK1/DAP Kinase 1
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背景
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Background: Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to the protein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK1 contains ten ANK repeats, one death domain and one protein kinase domain. DAPK1 is a calcium / calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. DAPK1 gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 gene has been found in many carcinomas. DAPK1 over-expression can induce cell apoptosis and inhibit tumor cell metastasis. DAPK1 gene over-expression could suppress PGCl3 cells malignant phenotype, inhibit PGCl3 cells growth, invasive, migration and adhesion ability, upregulate p53 gene and downregulate bcl-2 gene. Loss of activity of death-associated protein kinase 1 ( DAPK1 ) may be an independent factor affecting survival of non-small cell lung cancer patients. DAPK1 promoter methylation might play a significant role in the progression of chronic myeloid leukemia ( CML ).
Synonym: DAPK
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分子量
- 69.4 kDa
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途径
- MAPK Pathway, Interferon-gamma Pathway
抗原
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