CSF1R Protein (His-GST)
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北京 101111
Quick Overview for CSF1R Protein (His-GST) (ABIN7317115)
抗原
See all CSF1R 蛋白蛋白类型
宿主
资源
纯度
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标记
- This CSF1R protein is labelled with His-GST.
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原理
- Recombinant Human CSF1R/CD115 Protein (His & GST Tag)
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序列
- Lys 543-Cys 972
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产品特性
- A DNA sequence encoding the human CSF1R (NP_005202.2) cytoplasmic domain (Lys 543-Cys 972) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Colony Stimulating Factor 1 Receptor (CSF1R) (AA 99-596) (Active) protein (His tag)
CSF1R 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) (Active) protein (hFc Tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) (Active) protein (Biotin,His-Avi Tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-514) protein (His tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) (Active) protein (His-Avi Tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 99-596) protein (Fc Tag)CSF1R 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) protein (His tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant >96 % as determined by SDS-PAGE.
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-511) protein (His tag)CSF1R 宿主: 小鼠 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 1-510) (Active) protein (His tag)CSF1R 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. ELISA Active
Colony Stimulating Factor 1 Receptor (CSF1R) (Active) protein (His tag)CSF1R 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by reducing SDS-PAGE. ELISA Active
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 50 mM Tris, 150 mM NaCl, pH 7.4, 20 % glycerol, 0.3 mM DTT
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储存液
- Dithiothreitol (DTT)
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注意事项
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
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别名
- CSF1R/CD115
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背景
- C-FMS;CD115;CSF-1 receptor;CSF-1-R;CSF-1R;CSF1R;FIM2;FMS;HDLS;M-CSF-R;MCSF Receptor ;Macrophage colony-stimulating factor 1 receptor;Proto-oncogene c-Fms,M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation.
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分子量
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Calculated MW: 76 kDa
Observed MW: 75 kDa
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基因ID
- 1436
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NCBI登录号
- NP_005202
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UniProt
- P07333
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途径
- RTK signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
抗原
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