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CDC37 蛋白

CDC37 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 85 % as determined by SDS-PAGE
产品编号 ABIN7195023
发货至: 中国
  • 抗原 See all CDC37 蛋白
    CDC37 (Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37))
    蛋白类型
    Recombinant
    宿主
    • 5
    • 1
    • 1
    • 1
    • 1
    小鼠
    资源
    • 3
    • 3
    • 2
    • 1
    Baculovirus infected Insect Cells
    原理
    Recombinant Mouse CDC37/CDC37A Protein
    序列
    Met1-Ala379
    产品特性
    A DNA sequence encoding the mouse CDC37 (Q61081) (Met1-Ala379) was expressed with two additional amino acids (Gly & Pro) at the N-terminus.
    纯度
    > 85 % as determined by SDS-PAGE
    内毒素水平
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Top Product
    Discover our top product CDC37 蛋白
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    Product
    表达系统
    Conjugate
    Origin
    价格从
    表达系统 HEK-293 Cells
    Conjugate His tag
    Origin Mouse
    价格从 115,504.49 ¥

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  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    CDC37 (Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37))
    别名
    CDC37/CDC37A (CDC37 产品)
    背景

    Background: CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is though to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified to Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.

    Synonym: p50,p50Cdc37

    分子量
    44.7 kDa
    UniProt
    Q61081
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