Quick Overview for CD68 Protein (Fc Tag) (ABIN7321139)
抗原
See all CD68 蛋白蛋白类型
宿主
资源
纯度
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标记
- This CD68 protein is labelled with Fc Tag.
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原理
- Recombinant Rat CD68/Macrosialin Protein (Fc Tag)
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序列
- Met1-Ser295
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产品特性
- A DNA sequence encoding the rat CD68 (Q4FZY1) (Met1-Ser295) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
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CD68 Molecule (CD68) (AA 22-319) protein (His tag)
CD68 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95% by SDS-PAGE SDS
CD68 Molecule (CD68) protein (His tag)CD68 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
CD68 Molecule (CD68) (AA 22-319) protein (His tag)CD68 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- CD68 (CD68 Molecule (CD68))
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别名
- CD68/Macrosialin
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背景
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Background: Macrosialin, also known as CD68 and Gp110, is a single-pass type I membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Synonym: CD68
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分子量
- 56.5 kDa
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UniProt
- Q4FZY1
抗原
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