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PD-L1 Protein (His tag)

This Recombinant PD-L1 protein is expressed in 人细胞.
产品编号 ABIN7321268
发货至: 中国

Quick Overview for PD-L1 Protein (His tag) (ABIN7321268)

抗原

See all PD-L1 蛋白
PD-L1 (CD274 (PD-L1))

蛋白类型

Recombinant

宿主

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大鼠

资源

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人细胞

纯度

> 95 % as determined by reducing SDS-PAGE.
  • 标记

    This PD-L1 protein is labelled with His tag.

    原理

    Recombinant Rat PD-L1/B7-H1/CD274 Protein (C-His)

    序列

    Ala18-Thr238

    产品特性

    Recombinant Rat PD-L1 is produced by our Mammalian expression system and the target gene encoding Ala18-Thr238 is expressed with a 6His tag at the C-terminus.

    内毒素水平

    < 1.0 EU per μg as determined by the LAL method.
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Please refer to the printed manual for detailed information.

    缓冲液

    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

    储存条件

    4 °C,-20 °C,-80 °C

    储存方法

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原

    PD-L1 (CD274 (PD-L1))

    别名

    PD-L1/B7-H1/CD274

    背景

    Background: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

    Synonym: B7-H,B7-H1,B7H1,PD-L1,PDCD1L1,PDCD1LG1,PDL1

    分子量

    26.1 kDa

    UniProt

    D4AE25

    途径

    Cancer Immune Checkpoints
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