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PD-L1 Protein (His tag)

Name: PD-L1 Protein (His tag)
Brand: antibodies-online
SKU: ABIN7194779
Availability: OutOfStock

This Recombinant PD-L1 protein is expressed in HEK-293 Cells.

Western Blotting (WB) image for CD274 (PD-L1) (Active) protein (His tag) (ABIN7194779) (PD-L1 Protein (His tag))

1 image

产品编号 ABIN7194779

发货至: 中国

Quick Overview for PD-L1 Protein (His tag) (ABIN7194779)

抗原

See all PD-L1 蛋白

PD-L1 (CD274 (PD-L1))

蛋白类型

Recombinant

生物活性

Active

宿主

小鼠

资源

HEK-293 Cells

纯度

> 98 % as determined by SDS-PAGE

Discover our top product PD-L1 蛋白

标记

This PD-L1 protein is labelled with His tag.

原理

Recombinant Mouse PD-L1/B7-H1/CD274 Protein (His Tag) (Active)

序列

Met 1-Thr 238

产品特性

A DNA sequence encoding the mouse CD274 (NP_068693.1) extracellular domain (Met 1-Thr 238) was fused with a polyhistidine tag at the C-terminus.

内毒素水平

< 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment

Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse PD1-L1 at 1 μg/ml (100 μl/well) can bind mouse PD1 with a linear range of 6.25-400 ng/ml.
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CD274 (PD-L1) (AA 19-238) protein (Fc Tag)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (His tag)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (His-Avi Tag,Biotin)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (His tag)
PD-L1 宿主: Cynomolgus, 猕猴宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (mFc Tag)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (mFc-His Tag)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA

CD274 (PD-L1) (AA 19-238) (Active) protein (His tag)
HPLC verified PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE. Active

CD274 (PD-L1) (AA 19-238) protein (Fc Tag)
PD-L1 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-237) protein (Fc Tag)
PD-L1 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (His tag)
PD-L1 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

限制

仅限研究用
状态

Lyophilized

溶解方式

Please refer to the printed manual for detailed information.

缓冲液

Lyophilized from sterile PBS, pH 7.4

储存条件

4 °C,-20 °C,-80 °C

储存方法

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
抗原

PD-L1 (CD274 (PD-L1))

别名

PD-L1/B7-H1/CD274

背景

Background: Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.Immune CheckpointImmune Checkpoint Blockade: Blocking Antibodies Immune Checkpoint Blockade: PD-L1 / B7-H1 / CD274 Blocking AntibodiesImmune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IHC Antibodies Immune Checkpoint Detection: ICC Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint Proteins PD-L1 / B7-H1 / CD274 Immune Checkpoint ProteinsImmune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: A530045L16Rik Protein, Mouse;B7h1 Protein, Mouse;Pdcd1l1 Protein, Mouse;Pdcd1lg1 Protein, Mouse;Pdl1 Protein, Mouse

分子量

26.3 kDa

NCBI登录号

NP_068693

途径

Cancer Immune Checkpoints