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Quick Overview for CD22 Protein (Fc Tag) (ABIN7320025)
抗原
See all CD22 蛋白蛋白类型
宿主
资源
纯度
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标记
- This CD22 protein is labelled with Fc Tag.
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原理
- Recombinant Mouse Siglec-2/CD22 Protein (Fc Tag)
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序列
- Met1-Arg708
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产品特性
- A DNA sequence encoding the mouse CD22 (BAE33829.1)(Met1-Arg708) was expressed with the Fc region of human IgG1 at the C-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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CD22 Molecule (CD22) (AA 20-687) protein (His-Avi Tag,Biotin)
CD22 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD22 Molecule (CD22) (AA 20-686) protein (His tag)CD22 宿主: 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
CD22 Molecule (CD22) (AA 20-687) protein (Fc-His Tag)CD22 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
CD22 Molecule (CD22) (AA 417-678) protein (mFc Tag)CD22 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
CD22 Molecule (CD22) (AA 417-678) protein (Fc Tag)CD22 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
CD22 Molecule (CD22) (AA 20-687) (Active) protein (His-Fc tag)CD22 宿主: 人 宿主: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, ELISA, SDS, Imm, AcA Active
CD22 Molecule (CD22) (AA 19-708) protein (His tag)CD22 宿主: 小鼠 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
CD22 Molecule (CD22) (Active) protein (His tag,Biotin)CD22 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE. Active
CD22 Molecule (CD22) (AA 20-687) protein (FITC,Fc Tag)CD22 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
CD22 Molecule (CD22) (AA 20-687) protein (hIgG-His-tag)CD22 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 85 % SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- CD22 (CD22 Molecule (CD22))
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别名
- Siglec-2/CD22
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背景
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Background: CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro. The phenotype of CD22-deficient mice suggests that CD22 is primarily involved in the generation of mature B cells within the bone marrow, blood, and marginal zones of lymphoid tissues. CD22 recruits the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) to immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and inhibits B-cell receptor (BCR)-induced Ca2+ signaling on normal B cells. CD22 interacts specifically with ligands carrying alpha2-6-linked sialic acids. As an inhibitory coreceptor of the B-cell receptor (BCR), CD22 plays a critical role in establishing signalling thresholds for B-cell activation. Like other coreceptors, the ability of CD22 to modulate B-cell signalling is critically dependent upon its proximity to the BCR, and this in turn is governed by the binding of its extracellular domain to alpha2,6-linked sialic acid ligands. However, genetic studies in mice reveal that some CD22 functions are regulated by ligand binding, whereas other functions are ligand-independent and may only require expression of an intact CD22 cytoplasmic domain at the B-cell surface. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: A530093D23;Lyb-8;Lyb8
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分子量
- 104.3 kDa
抗原
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