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CD2 Protein (CD2) (His tag)

CD2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE
产品编号 ABIN7320241
发货至: 中国
  • 抗原 See all CD2 蛋白
    CD2
    蛋白类型
    Recombinant
    宿主
    • 21
    • 3
    • 3
    • 1
    • 1
    小鼠
    资源
    • 11
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    HEK-293 Cells
    标记
    This CD2 protein is labelled with His tag.
    原理
    Recombinant Mouse CD2 Protein (His Tag)
    序列
    Met 1-Ser 203
    产品特性
    A DNA sequence encoding the extracellular domain of mouse CD2 (NP_038514.1) (Met 1-Ser 203) was expressed, with a polyhistidine tag at the C-terminus.
    纯度
    > 98 % as determined by SDS-PAGE
    内毒素水平
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Top Product
    Discover our top product CD2 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    CD2
    别名
    CD2 (CD2 产品)
    别名
    CD2 Protein, LFA-2 Protein, Ly-37 Protein, Ly37 Protein, SRBC Protein, T11 Protein, CD2R Protein, LFA2 Protein, OX-34 Protein, OX34 Protein, CD2 molecule Protein, CD2 antigen Protein, Cd2 molecule Protein, CD2 Protein, Cd2 Protein
    背景

    Background: T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). CD2 has been shown to set quantitative thresholds in T cell activation both in vivo and in vitro. Further, intracellular CD2 signaling pathways and networks are being discovered by the identification of several cytosolic tail binding proteins. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Synonym: LFA-2;Ly-37;Ly37

    分子量
    22 kDa
    NCBI登录号
    NP_038514
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