CTSA Protein (His tag)
Quick Overview for CTSA Protein (His tag) (ABIN7194664)
抗原
See all CTSA 蛋白蛋白类型
宿主
资源
纯度
-
-
标记
- This CTSA protein is labelled with His tag.
-
原理
- Recombinant Human Cathepsin A/CTSA Protein (His Tag)
-
序列
- Met 1-Tyr 480
-
产品特性
- A DNA sequence encoding the human cathepsin A isoform b (Met 1-Tyr 480) (NP_001121167.1) was expressed with a N-terminal signal peptide and a C-terminal polyhistidine tag.
-
内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
-
-
Cathepsin A (CTSA) (AA 1-480) protein (GST tag)
CTSA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cathepsin A (CTSA) (AA 24-474) protein (His tag)CTSA 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
Cathepsin A (CTSA) protein (His tag)CTSA 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 96 % as determined by SDS-PAGE
-
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Please refer to the printed manual for detailed information.
-
缓冲液
- Lyophilized from sterile 25 mM Tris, 0.15 mM NaCl, pH 7.5
-
储存条件
- 4 °C,-20 °C,-80 °C
-
储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
-
- CTSA (Cathepsin A (CTSA))
-
别名
- Cathepsin A/CTSA
-
背景
-
Background: Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. Cathepsin A is a multicatalytic enzyme with deamidase and esterase in addition to carboxypeptidase activities. It was recently identified in human platelets as deamidase. In vitro, it hydrolyzes a variety of bioactive peptide hormones including tachykinins, suggesting that extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions. It is a member of the alpha/beta hydrolase fold family and has been suggested to share a common ancestral relationship with other alpha/beta hydrolase fold enzymes, such as cholinesterases. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. Cathepsin A is a key molecule in the onset of galactosialidosis and also highlight the therapeutic acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.
Synonym: Lysosomal protective protein,CTSA,Carboxypeptidase C,Carboxypeptidase L,Cathepsin A,GLB2,GSL,NGBE,PPCA,PPGB
-
分子量
- 53 kDa
-
NCBI登录号
- NP_001121167
抗原
-
