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CTSA Protein (His tag)

CTSA 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 96 % as determined by SDS-PAGE
产品编号 ABIN7320306
发货至: 中国
  • 抗原 See all CTSA 蛋白
    CTSA (Cathepsin A (CTSA))
    蛋白类型
    Recombinant
    宿主
    • 9
    • 5
    • 2
    • 2
    • 2
    • 2
    小鼠
    资源
    • 12
    • 4
    • 3
    • 1
    • 1
    • 1
    HEK-293 Cells
    标记
    This CTSA protein is labelled with His tag.
    原理
    Recombinant Mouse Cathepsin A/CTSA Protein (His Tag)
    序列
    Met 1-Tyr 474
    产品特性
    A DNA sequence encoding the mouse CTSA (P16675-1) (Met 1-Tyr 474) was expressed, with a C-terminal polyhistidine tag.
    纯度
    > 96 % as determined by SDS-PAGE
    内毒素水平
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Top Product
    Discover our top product CTSA 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile 25 mM Tris, 0.3M NaCl, pH 8.0
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    CTSA (Cathepsin A (CTSA))
    别名
    Cathepsin A/CTSA (CTSA 产品)
    别名
    Ppgb Protein, beta-galactosidase 2 Protein, PPGB Protein, GLB2 Protein, GSL Protein, NGBE Protein, PPCA Protein, AU019505 Protein, cathepsin A Protein, beta-galactosidase 2 Protein, Ctsa Protein, BGAL2 Protein, CTSA Protein
    背景

    Background: Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. Cathepsin A is a multicatalytic enzyme with deamidase and esterase in addition to carboxypeptidase activities. It was recently identified in human platelets as deamidase. In vitro, it hydrolyzes a variety of bioactive peptide hormones including tachykinins, suggesting that extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions. It is a member of the alpha/beta hydrolase fold family and has been suggested to share a common ancestral relationship with other alpha/beta hydrolase fold enzymes, such as cholinesterases. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. Cathepsin A is a key molecule in the onset of galactosialidosis and also highlight the therapeutic acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.

    Synonym: AU019505,PPCA,Ppgb

    分子量
    52.8 kDa
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