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Quick Overview for BST2 Protein (Fc Tag) (ABIN7320063)
抗原
See all BST2 蛋白蛋白类型
宿主
资源
纯度
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标记
- This BST2 protein is labelled with Fc Tag.
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原理
- Recombinant Mouse TETHERIN/BST2 Protein (Fc Tag)
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序列
- Thr 52-Asn 151
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产品特性
- A DNA sequence encoding the extracellular domain of mouse BST2 (Q8R2Q8) (Thr 52-Asn 151) was fused with the Fc region of human IgG1 at the N-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 49-161) (Active) protein (hFc Tag)
BST2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 52-152) (Active) protein (hFc Tag)BST2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 52-152) (Active) protein (His tag)BST2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 49-163) (Active) protein (His tag)BST2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 40-180) protein (GST tag)BST2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 1-180) protein (GST tag)BST2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 50-161) protein (His tag)BST2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 80 % SDS
Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 99-330) protein (Fc Tag)BST2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))
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别名
- TETHERIN/BST2
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背景
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Background: BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demonstrated that knockdown of BST2 by siRNA inhibited cell proliferation, induced apoptosis and repressed cell motility in GC cells. In addition, the pro-tumor function of BST2 in GC was mediated partly through the NF-κB signaling. BST2 possesses the oncogenic potential in GC by regulating the proliferation, apoptosis, and migratory ability of GC cells, thereby BST2 could be a potential therapeutic target for the treatment of GC. IFN (interferon)-induced BST2 recruits the E3 ubiquitin ligase MARCH8 to catalyze the K27-linked ubiquitination of MAVS for CALCOCO2-directed autophagic degradation, hence inhibiting DDX58-mediated type I interferon signaling through a negative feedback loop. BST2 is a host protein with dual functions in response to viral infections: it traps newly assembled enveloped virions at the plasma membrane in infected cells, and it induces NF-κB activity, especially in the context of retroviral assembly. BST2 may induce or amplify proinflammatory signaling during Ebola virus infection, potentially contributing to the dysregulated cytokine response that is a hallmark of Ebola virus disease.
Synonym: 2310015I10Rik,Bst-2,C87040,CD317,DAMP-1,GREG
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分子量
- 40 kDa
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UniProt
- Q8R2Q8
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途径
- Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response
抗原
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