B-Cell Linker Protein (BLNK) (His tag)
Quick Overview for B-Cell Linker Protein (BLNK) (His tag) (ABIN7319686)
抗原
See all B-Cell Linker (BLNK) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This B-Cell Linker protein is labelled with His tag.
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原理
- Recombinant Human BLNK/Ly-57 Protein (His Tag)
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序列
- Met1-Ser456
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产品特性
- Recombinant Human BLNK is produced by our E.coli expression system and the target gene encoding Met1-Ser456 is expressed with a 6His tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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B-Cell Linker (BLNK) (AA 1-457) protein (His tag)
custom-made BLNK 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
B-Cell Linker (BLNK) (AA 1-456) protein (His tag)custom-made BLNK 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
B-Cell Linker (BLNK) (AA 1-456) protein (GST tag)BLNK 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
B-Cell Linker (BLNK) (AA 1-456) protein (His tag)BLNK 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM DTT, pH 7.2.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- B-Cell Linker (BLNK)
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别名
- BLNK/Ly-57
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背景
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Background: B-Cell Linker Protein (BLNK) is a cell membrane protein which contains 1 SH2 domain. BLNK is expressed in B cells and fibroblast cell lines, playing a important role in B cell receptor signaling. BLNK as a central linker protein, downstream of the B-cell receptor (BCR), bridges the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. BLNK associates with the activation of ERK/EPHB2, MAP kinase p38 and JNK, modulates AP1, NF-kappa-B and NFAT activation. BLNK involves in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. BLNK deficiency results in agammaglobulinemia type 4 and much more profound block in B-cell development.
Synonym: B-Cell Linker Protein, B-Cell Adapter Containing a SH2 Domain Protein, B-Cell Adapter Containing a Src Homology 2 Domain Protein, Cytoplasmic Adapter Protein, Src Homology 2 Domain-Containing Leukocyte Protein of 65 kDa, SLP-65, BLNK, BASH, SLP65
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分子量
- 51.5 kDa
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UniProt
- Q8WV28
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途径
- BCR Signaling
抗原
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