RAGE 蛋白
Our Local Distributor
北京 101111
Quick Overview for RAGE 蛋白 (ABIN7317516)
抗原
See all RAGE (AGER) 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
-
-
原理
- Recombinant Human AGER/RAGE Protein
-
序列
- Met 1-Ala 344
-
产品特性
- A DNA sequence encoding the mature form of human AGER (NP_001127.1) (Met1-Ala 344) was expressed with six amino acids (LEVLFQ) at the C-terminus.
-
过滤
- 0.2 μm filtered
-
内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
-
Biological Activity Comment
- 1. Measured by its ability to compete with Biotinylated recombinant human AGER for binding to immobilized recombinant human Fc-S100B in a functional ELISA. 2. Measured by its ability to compete with Biotinylated recombinant human AGER for binding to immobilized recombinant mouse S100B-Fc in a functional ELISA. 3. Measured by its ability to compete with Biotinylated recombinant human AGER for binding to immobilized recombinant human S100A1-Fc in a functional ELISA. 4. Measured by its ability to compete with Biotinylated recombinant human AGER for binding to immobilized recombinant human APP-Fc in a functional ELISA.
-
-
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-342) protein (His-DYKDDDDK-Strep II Tag)
AGER 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-342) (Active) protein (His tag)AGER 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-340) (Active) protein (His tag)AGER 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 134-231) protein (GST tag)AGER 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-237) protein (GST tag)AGER 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 24-344) (Active) protein (His-Fc tag)AGER 宿主: 人 宿主: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, Imm, ELISA, AcA Active
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-404) protein (GST tag)AGER 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 27-340) protein (His tag)AGER 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 362-404) protein (His-IF2DI Tag)AGER 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Advanced Glycosylation End Product-Specific Receptor (AGER) (Active) protein (His tag)AGER 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 96 % as determined by reducing SDS-PAGE. ELISA Active
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
-
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
-
储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
有效期
- 12 months
-
-
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
-
别名
- AGER/RAGE
-
背景
- AGER,Advanced Glycosylation End Product-Specific Receptor,RAGE,Receptor for Advanced Glycosylation End Products,Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certain members of the S100/calgranulin family of proteins, high mobility group box 1 (HMGB1), advanced oxidation protein products, and amyloid (beta-sheet fibrils). Initial studies investigating the role of RAGE in renal dysfunction focused on diabetes, neurodegenerative disorders, and inflammatory responses. However, RAGE also has roles in the pathogenesis of renal disorders that are not associated with diabetes, such as obesity-related glomerulopathy, doxorubicin-induced nephropathy, hypertensive nephropathy, lupus nephritis, renal amyloidosis, and ischemic renal injuries. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases.
-
分子量
-
Calculated MW: 35.0 kDa
Observed MW: 46-52 kDa
-
NCBI登录号
- NP_001127
-
途径
- Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
抗原
-
