AK4 蛋白
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- 抗原 See all AK4 蛋白
- AK4 (Adenylate Kinase 4 (AK4))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 原理
- Recombinant Human AK4/AK3L1 Protein
- 序列
- Ala 2-Tyr 223
- 产品特性
- A DNA sequence encoding the human AK4 (P27144-1) (Ala 2-Tyr 223) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product AK4 蛋白
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Adenylate Kinase 4 (AK4) (AA 1-223) protein (His tag)
AK4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Adenylate Kinase 4 (AK4) (AA 1-223) protein (GST tag)AK4 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Adenylate Kinase 4 (AK4) (AA 1-110) protein (GST tag)AK4 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Adenylate Kinase 4 (AK4) protein (GST tag,His tag)AK4 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 94 % as determined by reducing SDS-PAGE.
Adenylate Kinase 4 (AK4) (AA 1-223) protein (Strep Tag)Crystallography grade AK4 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Adenylate Kinase 4 (AK4) (Transcript Variant 6) protein (Myc-DYKDDDDK Tag)AK4 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Adenylate Kinase 4 (AK4) (Transcript Variant 5) protein (Myc-DYKDDDDK Tag)AK4 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- AK4 (Adenylate Kinase 4 (AK4))
- 别名
- AK4/AK3L1 (AK4 产品)
- 别名
- AK 4 Protein, AK3 Protein, AK3L1 Protein, AK3L2 Protein, ak3l1 Protein, wu:fc37g02 Protein, zgc:85790 Protein, AK4 Protein, Ak-3 Protein, Ak-4 Protein, Ak3 Protein, Ak3l1 Protein, D4Ertd274e Protein, Ak3l2 Protein, adenylate kinase 4 Protein, AK4 Protein, ak4 Protein, Ak4 Protein, ADK4 Protein
- 背景
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Background: Adenylate kinase isoenzyme 4; mitochondrial; also known as ATP-AMP transphosphorylase; Adenylate kinase 3-like; AK4 and AK3L1; is a member the adenylate kinase family. AK4 / AK3L1 is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. AK4 / AK3L1 catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. It may also be active with GTP. Adenylate kinase 4 ( AK4 / AK3L1 ) is a unique member with no enzymatic activity in the adenylate kinase (AK) family although it shares high sequence homology with other AKs. It remains unclear what physiological function AK4 might play or why it is enzymatically inactive. AK4 / AK3L1 retains the capability of binding nucleotides. It has a glutamine residue instead of a key arginine residue in the active site well conserved in other AKs. The enzymatically inactive AK4 is a stress responsive protein critical to cell survival and proliferation. AK4 / AK3L1 is likely that the interaction with the mitochondrial inner membrane protein ANT is important for AK4 to exert the protective benefits to cells under stress. AK4 / AK3L1 also acts on the specific mechanism of energy metabolism rather than control of the homeostasis of the ADP pool ubiquitously.
Synonym: AK3;AK3L1;AK3L2;AK4
- 分子量
- 25.3 kDa
- 途径
- Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process
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