AK4 Protein (His-GST)
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北京 101111
Quick Overview for AK4 Protein (His-GST) (ABIN7194160)
抗原
See all AK4 蛋白蛋白类型
宿主
资源
纯度
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标记
- This AK4 protein is labelled with His-GST.
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原理
- Recombinant Human AK4/AK3L1 Protein (His & GST Tag)
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序列
- Ala 2-Tyr 223
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产品特性
- A DNA sequence encoding the human AK4 (P27144-1) (Ala 2-Tyr 223) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 116,946.14 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Adenylate Kinase 4 (AK4) (AA 1-223) protein (His tag)
custom-made AK4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Adenylate Kinase 4 (AK4) (AA 1-223) protein (His tag)custom-made AK4 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Adenylate Kinase 4 (AK4) (AA 1-223) protein (GST tag)AK4 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Adenylate Kinase 4 (AK4) (AA 1-223) protein (His tag)AK4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Adenylate Kinase 4 (AK4) (AA 1-223) protein (His-IF2DI Tag)AK4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Adenylate Kinase 4 (AK4) (AA 1-223), (C22S) protein (His tag)AK4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, pH 8.0
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- AK4 (Adenylate Kinase 4 (AK4))
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别名
- AK4/AK3L1
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背景
- AK3,AK3L1,AK3L2,AK4,Adenylate kinase isoenzyme 4, mitochondrial, also known as ATP-AMP transphosphorylase, Adenylate kinase 3-like, AK4 and AK3L1, is a member theadenylate kinase family. AK4 / AK3L1 is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. AK4 / AK3L1 catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. It may also be active with GTP. Adenylate kinase 4 ( AK4 / AK3L1 ) is a unique member with no enzymatic activity in the adenylate kinase (AK) family although it shares high sequence homology with other AKs. It remains unclear what physiological function AK4 might play or why it is enzymatically inactive. AK4 / AK3L1 retains the capability of binding nucleotides. It has a glutamine residue instead of a key arginine residue in the active site well conserved in other AKs. The enzymatically inactive AK4 is a stress responsive protein critical to cell survival and proliferation. AK4 / AK3L1 is likely that the interaction with the mitochondrial inner membrane protein ANT is important for AK4 to exert the protective benefits to cells under stress. AK4 / AK3L1 also acts on the specific mechanism of energy metabolism rather than control of the homeostasis of the ADP pool ubiquitously.
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分子量
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Calculated MW: 53.0 kDa
Observed MW: 46 kDa
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基因ID
- 205
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UniProt
- P27144
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途径
- Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process
抗原
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