Activin RIIA / ACVR2A (Active) protein (His tag)
-
- 抗原
- Activin RIIA / ACVR2A
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 小鼠
-
资源
- HEK-293 Cells
- 标记
- His tag
- 原理
- Recombinant Mouse Activin RIIA/ACVR2A Protein (His Tag)(Active)
- 序列
- Met 1-Pro 134
- 产品特性
- A DNA sequence encoding the extracellular domain of mouse ACVR2A (NP_031422.3) (Met 1-Pro 134) was expressed, with a C-terminal polyhistidine tag.
- 纯度
- > 97 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.The ED50 for this effect is typically 0.6-3 μg/mL in the presence of 10 ng/ml Recombinant Human Activin A.
-
Activin RIIA / ACVR2A (Active) protein (His tag,Fc Tag)
宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- Activin RIIA / ACVR2A
- 别名
- Activin RIIA/ACVR2A
- 背景
-
Background: ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98 % identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.
Synonym: ActrIIa,Acvr2,TactrII
- 分子量
- 14.8 kDa
- NCBI登录号
- NP_031422
-
