14-3-3 theta Protein (YWHAQ) (GST tag)
Quick Overview for 14-3-3 theta Protein (YWHAQ) (GST tag) (ABIN7317745)
抗原
See all 14-3-3 theta (YWHAQ) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This 14-3-3 theta protein is labelled with GST tag.
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原理
- Recombinant Human 14-3-3 tau/14-3-3 theta/YWHAQ Protein (GST Tag)
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序列
- Met 1-Asn 245
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产品特性
- A DNA sequence encoding the human YWHAQ (P27348) (Met 1-Asn 245) was fused with the GST tag at the N-terminus.
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14-3-3 theta (YWHAQ) (AA 1-245) protein (His tag)
custom-made YWHAQ 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
14-3-3 theta (YWHAQ) (AA 1-245) protein (His tag)custom-made YWHAQ 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
14-3-3 theta (YWHAQ) (AA 1-245) protein (His tag)YWHAQ 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
14-3-3 theta (YWHAQ) (AA 1-245) protein (GST tag)YWHAQ 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
14-3-3 theta (YWHAQ) (AA 1-245) proteinYWHAQ 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % pure SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile 20 mM Tris, 0.15m NaCl, 20 mM GSH, pH 7.5
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 14-3-3 theta (YWHAQ)
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别名
- 14-3-3 tau/14-3-3 theta/YWHAQ
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背景
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Background: G protein-coupled receptor kinase 5, also known as G protein-coupled receptor kinase GRK5 and GRK5, is a member of the protein kinase superfamily, AGC Ser/Thr protein kinase family and GPRK subfamily. GRKs specifically phosphorylate agonist-occupied G protein-coupled receptors at the inner surface of the plasma membrane (PM), leading to receptor desensitization. GRKs utilize a variety of mechanisms to bind tightly, and sometimes reversibly, to cellular membranes. GRKs play an important role in mediating agonist-specific desensitization of numerous G protein-coupled receptors. GRK5 contains one AGC-kinase C-terminal domain, one protein kinase domain and one RGS domain. GRK5 specifically phosphorylates the activated forms of G protein-coupled receptors. Phospholipid-stimulated autophosphorylation may represent a novel mechanism for membrane association and regulation of GRK5 activity. GRK5 deficiency significantly exaggerates microgliosis and astrogliosis in the presence of an inflammatory initiator, such as the excess fibrillar Abeta and the subsequent active inflammatory reactions. GRK5 deficiency has been linked to early Alzheimer's disease in humans and mouse models of the disease.
Synonym: 1C5;41701;HS1
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分子量
- 54.6 kDa
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UniProt
- P27348
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途径
- Apoptosis, Myometrial Relaxation and Contraction
抗原
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