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IL-4 Protein (Fc Tag)

This Recombinant IL-4 protein is expressed in HEK-293 Cells.
产品编号 ABIN7125955
发货至: 中国

Quick Overview for IL-4 Protein (Fc Tag) (ABIN7125955)

抗原

See all IL-4 (IL4) 蛋白
IL-4 (IL4) (Interleukin 4 (IL4))

蛋白类型

Recombinant

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Cynomolgus

资源

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HEK-293 Cells

纯度

>90 % as determined by SDS-PAGE.

质量等级

MALS verified
  • 标记

    This IL-4 protein is labelled with Fc Tag.

    原理

    Cynomolgus IL-4 Protein, Fc Tag (MALS verified)

    序列

    His 25 - Ser 153

    产品特性

    Cynomolgus IL-4, Fc Tag is expressed from human 293 cells (HEK293). It contains AA His 25 - Ser 153 (Accession # P79339-1).

    内毒素水平

    Less than 1.0 EU per μg by the LAL method.
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  • 应用备注

    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.4 kDa. The protein migrates as 46-50 kDa and 53 kDa under reducing (R) condition due to glycosylation.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5

    储存条件

    -20 °C

    储存方法

    -20°C
  • 抗原

    IL-4 (IL4) (Interleukin 4 (IL4))

    别名

    IL-4

    背景

    Synonyms: IL4,BCGF1,BSF1,
    Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

    分子量

    41.4 kDa

    途径

    JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation
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