IL-4 Protein (Fc Tag)
Quick Overview for IL-4 Protein (Fc Tag) (ABIN7125955)
抗原
See all IL-4 (IL4) 蛋白蛋白类型
宿主
资源
纯度
质量等级
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标记
- This IL-4 protein is labelled with Fc Tag.
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原理
- Cynomolgus IL-4 Protein, Fc Tag (MALS verified)
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序列
- His 25 - Ser 153
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产品特性
- Cynomolgus IL-4, Fc Tag is expressed from human 293 cells (HEK293). It contains AA His 25 - Ser 153 (Accession # P79339-1).
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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应用备注
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.4 kDa. The protein migrates as 46-50 kDa and 53 kDa under reducing (R) condition due to glycosylation.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
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储存条件
- -20 °C
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储存方法
- -20°C
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- IL-4 (IL4) (Interleukin 4 (IL4))
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别名
- IL-4
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背景
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Synonyms: IL4,BCGF1,BSF1,
Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen. -
分子量
- 41.4 kDa
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途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation
抗原
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