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PD-L1 Protein (His-Avi Tag,Biotin)

Name: PD-L1 Protein (His-Avi Tag,Biotin)
SKU: ABIN7199143
Availability: OutOfStock

This Recombinant PD-L1 protein is expressed in HEK-293 Cells.

产品编号 ABIN7199143

发货至: 中国

Quick Overview for PD-L1 Protein (His-Avi Tag,Biotin) (ABIN7199143)

抗原

See all PD-L1 蛋白

PD-L1 (CD274 (PD-L1))

蛋白类型

Recombinant

宿主

Cynomolgus, 猕猴

资源

HEK-293 Cells

纯度

>90 % as determined by SDS-PAGE.

质量等级

MALS verified

Discover our top product PD-L1 蛋白

标记

This PD-L1 protein is labelled with His-Avi Tag,Biotin.

原理

Biotinylated Cynomolgus / Rhesus macaque PD-L1 / B7-H1 Protein, His,Avitag™ (MALS verified)

序列

Phe 19 - Arg 238

产品特性

Biotinylated Cynomolgus / Rhesus macaque PD-L1, His,Avitag (PDL-C82E8) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Arg 238 (Accession # G7PSE7-1).

内毒素水平

Less than 1.0 EU per μg by the LAL method.
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CD274 (PD-L1) (AA 19-238) protein (Fc Tag)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (His tag)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (His-Avi Tag,Biotin)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (His tag)
PD-L1 宿主: Cynomolgus, 猕猴宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (mFc Tag)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (mFc-His Tag)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA

CD274 (PD-L1) (AA 19-238) (Active) protein (His tag)
HPLC verified PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE. Active

CD274 (PD-L1) (AA 19-238) protein (Fc Tag)
PD-L1 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-237) protein (Fc Tag)
PD-L1 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (His tag)
PD-L1 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

应用备注

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 28.8 kDa. The protein migrates as 32-40 kDa under reducing (R) condition due to glycosylation.

说明

Ready-to-use Avitag™ biotinylated protein:
The product is exclusively produced using the Avitag™ technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

限制

仅限研究用
状态

Lyophilized

缓冲液

PBS, pH 7.4

储存条件

-20 °C

储存方法

-20°C
抗原

PD-L1 (CD274 (PD-L1))

别名

PD-L1 / B7-H1

背景

Synonyms: PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1,
Description: Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.

分子量

28.8 kDa

途径

Cancer Immune Checkpoints