EGFRviii Protein (Fc Tag)
Quick Overview for EGFRviii Protein (Fc Tag) (ABIN7199068)
抗原
蛋白类型
宿主
资源
纯度
质量等级
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标记
- This EGFRviii protein is labelled with Fc Tag.
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原理
- Human EGFRvIII Protein, Fc Tag (MALS verified)
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序列
- Leu 25- Ser 378
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产品特性
- Human EGFRvIII, Fc Tag (EGI-H5255) is expressed from human 293 cells (HEK293). It contains AA Leu 25- Ser 378 (Accession # NP_001333870.1).
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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EGFR vIII (EGFRv3) (AA 25-378) protein (His-Avi Tag,Biotin)
EGFRv3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EGFR vIII (EGFRv3) (AA 25-378) protein (His-Avi Tag)EGFRv3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EGFR vIII (EGFRv3) (AA 25-378) protein (FITC,His-Avi Tag)EGFRv3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
EGFR vIII (EGFRv3) (AA 25-645) protein (His tag)EGFRv3 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
EGFR vIII (EGFRv3) (AA 25-378) protein (PE,His-Avi Tag)EGFRv3 宿主: 人 宿主: HEK-293 Cells Recombinant
EGFR vIII (EGFRv3) (AA 25-378) (Active) protein (His tag,FITC)EGFRv3 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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应用备注
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 65.1 kDa. The protein migrates as 90-100 kDa under reducing (R) condition due to glycosylation.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
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储存条件
- -20 °C
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储存方法
- -20°C
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- EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))
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别名
- EGFRvIII
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背景
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Synonyms: EGFRvIII,
Description: The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. The type III EGF deletion-mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors, EGFR gene amplification is correlated with the structural rearrangement of the gene. The EGFRvIII gene has an in-frame deletion of 801 base pairs, corresponding to exons 2-7 in the mRNA, resulting in the deletion of amino acids 30-297 in the extracellular domain and the generation of a glycine at the fusion point -
分子量
- 65.1 kDa
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NCBI登录号
- NP_001333870
抗原
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