Quick Overview for CCL4 Protein (AA 24-92) (ABIN6952197)
抗原
See all CCL4 蛋白
CCL4
(Chemokine (C-C Motif) Ligand 4 (CCL4))
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
大肠杆菌（E. Coli）
应用范围
Cell Migration Assay (CMA)
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产品特性
- AA 24-92
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序列
- APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN
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产品特性
- Recombinant Human CCL4 (MIP-1beta)
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内毒素水平
- <0.01 EU per 1μg of the protein by the LAL method
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Biological Activity Comment
- EC50 = 0.23 nM determined by Calcium Flux
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Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) (Active) protein (Biotin)
CCL4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 97 % by SDS PAGE CMA Active
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water
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储存条件
- -20 °C,-80 °C
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储存方法
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12 months from date of receipt, -20 to -70 °C as supplied.
Suggest to use immediately after reconstitution
1 month at -20 to -70 °C under sterile conditions after reconstitution. -
有效期
- 12 months
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- CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))
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别名
- CCL4 (MIP-1beta)
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背景
- Monokine with inflammatory and chemokinetic properties binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta (3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
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分子量
- 7.818 kDa
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UniProt
- P13236
抗原
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