ErbB2/Her2 Protein (AA 23-652)
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Quick Overview for ErbB2/Her2 Protein (AA 23-652) (ABIN6809903)
抗原
See all ErbB2/Her2 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 23-652
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序列
- AA 23-652
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (His-Avi Tag)
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (His-Avi Tag,Biotin)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (His tag)ErbB2/Her2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (Fc Tag)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 489-630) protein (His-Avi Tag)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (His tag)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 1-1255) protein (GST tag)ErbB2/Her2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 489-630) protein (His-Avi Tag,Biotin)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) (Active) protein (Fc Tag)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-510) (Active) protein (His tag)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, pH 7.4
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注意事项
- Please avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." in: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).
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: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." in: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
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- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
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别名
- Her2
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背景
- Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30 % of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .
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分子量
- 70.1 kDa
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NCBI登录号
- NP_004439
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
抗原
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