CD25 Protein (AA 22-236) (His tag)
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Quick Overview for CD25 Protein (AA 22-236) (His tag) (ABIN6809868)
抗原
See all CD25 (IL2RA) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 22-236
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标记
- This CD25 protein is labelled with His tag.
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序列
- AA 22-236
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, pH 7.4
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注意事项
- Please avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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- CD25 (IL2RA) (Interleukin 2 Receptor, alpha (IL2RA))
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别名
- IL-2 R alpha
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背景
- Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.
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分子量
- 26.6 kDa
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NCBI登录号
- NP_032393
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途径
- JAK/STAT Signaling, Growth Factor Binding, Activated T Cell Proliferation
抗原
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