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PD-L1 Protein (AA 19-238)

Name: PD-L1 Protein (AA 19-238)
Brand: antibodies-online
SKU: ABIN6253363
Availability: OutOfStock

This Recombinant PD-L1 protein is expressed in HEK-293 Cells.

产品编号 ABIN6253363

发货至: 中国

Quick Overview for PD-L1 Protein (AA 19-238) (ABIN6253363)

抗原

See all PD-L1 蛋白

PD-L1 (CD274 (PD-L1))

蛋白类型

Recombinant

宿主

人

资源

HEK-293 Cells

纯度

>95 % (SDS-PAGE)

Discover our top product PD-L1 蛋白

产品特性

AA 19-238

原理

CD274 [B7-H1/PD-L1] (human) (rec.)

特异性

The extracellular domain of human CD274 [B7-H1] (aa 19-238) is untagged.

产品特性

Protein. The extracellular domain of human CD274 [B7-H1] (aa 19-238) is untagged. Source: HEK 293 cells. Endotoxin content: <0.01EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >95 % (SDS-PAGE). Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. CD274 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. CD274 expression is also induced in dendritic cells and keratinocytes after IFN-gamma stimulation. CD274 expression is also upregulated in a variety of tumor cell lines. Interaction of CD274 with PD-1 results in inhibition of TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. The CD274 - PD-1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.

内毒素水平

<0.01EU/μg protein (LAL test, Lonza).

Biological Activity Comment

Measured by its ability to inhibit anti-CD3 antibody induced IL-2 secretion in human T lymphocytes.
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CD274 (PD-L1) (AA 19-238) protein (Fc Tag)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (His tag)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (His-Avi Tag,Biotin)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (His tag)
PD-L1 宿主: Cynomolgus, 猕猴宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (mFc Tag)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (mFc-His Tag)
PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA

CD274 (PD-L1) (AA 19-238) (Active) protein (His tag)
HPLC verified PD-L1 宿主: 人宿主: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE. Active

CD274 (PD-L1) (AA 19-238) protein (Fc Tag)
PD-L1 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-237) protein (Fc Tag)
PD-L1 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD274 (PD-L1) (AA 19-238) protein (His tag)
PD-L1 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

限制

仅限研究用
状态

Lyophilized

浓度

Lot specific

缓冲液

Lyophilized from 0.2μm-filtered solution in PBS.

注意事项

Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions.

储存条件

4 °C,-20 °C

储存方法

Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
抗原

PD-L1 (CD274 (PD-L1))

别名

CD274 [B7-H1/PD-L1]

背景

Alternate Names/Synonyms: PD-L1, Programmed Cell Death 1 Ligand Protein 1, PDCD1 Ligand 1, B7-H1, PDL1
Product Description: Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. CD274 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. CD274 expression is also induced in dendritic cells and keratinocytes after IFN-gamma stimulation. CD274 expression is also upregulated in a variety of tumor cell lines. Interaction of CD274 with PD-1 results in inhibition of TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. The CD274 - PD-1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.

分子量

~35kDa (SDS-PAGE)

NCBI登录号

NP_054862

途径

Cancer Immune Checkpoints