PD-1 Protein (AA 25-167)
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北京 101111
Quick Overview for PD-1 Protein (AA 25-167) (ABIN6253229)
抗原
See all PD-1 (PDCD1) 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 25-167
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原理
- CD279 [PD-1] (human) (rec.)
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特异性
- The extracellular domain of human CD279 [PD-1] (aa 25-167) is untagged.
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产品特性
- Protein. The extracellular domain of human CD279 [PD-1] (aa 25-167) is untagged. Source: HEK 293 cells. Endotoxin content: <0.01EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >95 % (SDS-PAGE). CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
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内毒素水平
- <0.01EU/μg protein (LAL test, Lonza).
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Biological Activity Comment
- Measured by its binding ability in a functional ELISA.
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Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (mFc Tag)
PDCD1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Programmed Cell Death 1 (PDCD1) (AA 21-167) protein (Fc Tag)PDCD1 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (Fc-Avi Tag,Biotin)PDCD1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (His-Avi Tag,Biotin)PDCD1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (Fc-His Tag)PDCD1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Programmed Cell Death 1 (PDCD1) (AA 24-170) protein (mFc-His Tag)PDCD1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (Fc Tag,Biotin)PDCD1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Programmed Cell Death 1 (PDCD1) (AA 1-110) protein (GST tag)PDCD1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Programmed Cell Death 1 (PDCD1) (AA 33-145) protein (His-DYKDDDDK-Strep II Tag)PDCD1 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Programmed Cell Death 1 (PDCD1) (AA 22-170) protein (His-DYKDDDDK-Strep II Tag)PDCD1 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
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限制
- 仅限研究用
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状态
- Lyophilized
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浓度
- Lot specific
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缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
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注意事项
- Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
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别名
- CD279 [PD-1]
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背景
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Alternate Names/Synonyms: PD-1, Programmed Cell Death Protein 1
Product Description: CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
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分子量
- ~30kDa (SDS-PAGE)
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NCBI登录号
- NP_005009
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途径
- Cancer Immune Checkpoints
抗原
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