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PD-1 Protein (AA 25-167)

Name: PD-1 Protein (AA 25-167)
Brand: antibodies-online
SKU: ABIN6253229
Availability: OutOfStock

This Recombinant PD-1 protein is expressed in HEK-293 Cells.

产品编号 ABIN6253229

发货至: 中国

Quick Overview for PD-1 Protein (AA 25-167) (ABIN6253229)

抗原

See all PD-1 (PDCD1) 蛋白

PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

蛋白类型

Recombinant

宿主

人

资源

HEK-293 Cells

纯度

>95 % (SDS-PAGE)

Discover our top product PDCD1 蛋白

产品特性

AA 25-167

原理

CD279 [PD-1] (human) (rec.)

特异性

The extracellular domain of human CD279 [PD-1] (aa 25-167) is untagged.

产品特性

Protein. The extracellular domain of human CD279 [PD-1] (aa 25-167) is untagged. Source: HEK 293 cells. Endotoxin content: <0.01EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >95 % (SDS-PAGE). CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

内毒素水平

<0.01EU/μg protein (LAL test, Lonza).

Biological Activity Comment

Measured by its binding ability in a functional ELISA.
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Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (Fc Tag)
PDCD1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (His tag)
PDCD1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (mFc Tag)
PDCD1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Programmed Cell Death 1 (PDCD1) (AA 21-167) protein (Fc Tag)
PDCD1 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (Fc-Avi Tag,Biotin)
PDCD1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (His-Avi Tag,Biotin)
PDCD1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (Fc-His Tag)
PDCD1 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining. ELISA

Programmed Cell Death 1 (PDCD1) (AA 24-170) protein (mFc-His Tag)
PDCD1 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA

Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (Fc Tag)
PDCD1 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (Fc Tag,Biotin)
PDCD1 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

限制

仅限研究用
状态

Lyophilized

浓度

Lot specific

缓冲液

Lyophilized from 0.2μm-filtered solution in PBS.

注意事项

Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions.

储存条件

4 °C,-20 °C

储存方法

Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
抗原

PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

别名

CD279 [PD-1]

背景

Alternate Names/Synonyms: PD-1, Programmed Cell Death Protein 1
Product Description: CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

分子量

~30kDa (SDS-PAGE)

NCBI登录号

NP_005009

途径

Cancer Immune Checkpoints