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FLT1 Protein (AA 27-756) (His tag,AVI tag,Biotin)

This Recombinant FLT1 protein is expressed in HEK-293 Cells.
产品编号 ABIN5955009
发货至: 中国

Quick Overview for FLT1 Protein (AA 27-756) (His tag,AVI tag,Biotin) (ABIN5955009)

抗原

See all FLT1 蛋白
FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

蛋白类型

Recombinant

生物活性

Active

宿主

  • 23
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资源

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HEK-293 Cells

纯度

>90 % as determined by SDS-PAGE.
  • 产品特性

    AA 27-756

    标记

    This FLT1 protein is labelled with His tag,AVI tag,Biotin.

    序列

    AA 27-756

    特异性

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

    内毒素水平

    Less than 1.0 EU per μg by the LAL method.
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  • 说明

    Ready-to-use AvitagTM biotinylated protein:
    The product is exclusively produced using the AvitagTM technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

    This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    PBS, pH 7.4

    注意事项

    Please avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C
  • 抗原

    FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

    别名

    VEGF R1

    背景

    Vascular endothelial growth factor receptor 1 (VEGFR1) is also known as Fms-like tyrosine kinase 1 (FLT-1), Tyrosine-protein kinase receptor FLT, is a single-pass type I membrane protein and secreted protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR1 is detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues and specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR1 acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR1 may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. VEGFR1 can promote endothelial cell proliferation, survival and angiogenesis in adulthood.

    分子量

    85.9 kDa

    NCBI登录号

    NP_002010

    途径

    RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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