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Prolactin Protein (PRL) (AA 29-227) (Fc Tag,AVI tag,Biotin)

This Recombinant Prolactin protein is expressed in HEK-293 Cells.
产品编号 ABIN5954928
发货至: 中国

Quick Overview for Prolactin Protein (PRL) (AA 29-227) (Fc Tag,AVI tag,Biotin) (ABIN5954928)

抗原

See all Prolactin (PRL) 蛋白
Prolactin (PRL)

蛋白类型

Recombinant

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HEK-293 Cells

纯度

>95 % as determined by SDS-PAGE.
  • 产品特性

    AA 29-227

    标记

    This Prolactin protein is labelled with Fc Tag,AVI tag,Biotin.

    序列

    AA 29-227

    特异性

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

    内毒素水平

    Less than 1.0 EU per μg by the LAL method.
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  • 说明

    Ready-to-use AvitagTM biotinylated protein:
    The product is exclusively produced using the AvitagTM technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

    This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    Tris with Glycine, Arginine and NaCl,  pH 7.5

    注意事项

    Please avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C
  • 抗原

    Prolactin (PRL)

    别名

    Prolactin

    背景

    Prolactin (gene name PRL) is a secreted neuroendocrine pituitary hormone that acts primarily on the mammary gland to promote lactation, but has pleiotropic effects in both males and females. Prolactin is synthesized as a prohormone. Following cleavage of the signal peptide, the length of the mature hormone is between 194 and 199 amino acids, depending on species. Hormone structure is stabilized by three intramolecular disulfide bonds. Excessive secretion of prolactin - hyperprolactinemia - is a relative common disorder in humans. This condition has numerous causes, including prolactin-secreting tumors and therapy with certain drugs. The prolactin receptor (gene name PRLR) is a transmembrane type I glycoprotein that belongs to the cytokine hematopoietic receptor family. Expression of the prolactin receptor is widespread. Each prolactin molecule is thought to bind two receptor molecules

    分子量

    51.2 kDa

    NCBI登录号

    NP_000939

    途径

    JAK/STAT Signaling, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Protein targeting to Nucleus
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