PLG 蛋白
Quick Overview for PLG 蛋白 (ABIN2830498)
抗原
See all PLG 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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序列
- VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPATHPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD ILECEEECMH CSGENYDGKI SKTMSGLECQ AWDSQSPHAH GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGPTYQCLK GTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT TNSQVRWEYC KIPSCDSSP
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产品特性
- Biological Activity: Fully biologically active when compared to standard. The specific activity determined by an assay on anti-proliferation and anti-migration using endothelial cells in vitro and anti-angiogenesis in vivo is 5.5 x 105 IU/mg.
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过滤
- 0.2 μm filtered
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Plasminogen (PLG) (AA 98-356) protein (His tag)
PLG 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Plasminogen (PLG) (AA 1-810) protein (GST tag)PLG 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Plasminogen (PLG) (AA 100-352) protein (His tag)PLG 宿主: 人 宿主: Yeast (Pichia pastoris) Recombinant > 95 % WB, SDS, ELISA, IP
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 20 mM NaAc, pH 5.5, 4 % mannitol
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储存条件
- -20 °C
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- PLG (Plasminogen (PLG))
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别名
- PLG
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背景
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Relevance: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093}., Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. {ECO:0000269|PubMed:14699093}.
Synonyms: EC 3.4.21.7, -
分子量
- 29.7 kDa
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UniProt
- P00747
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途径
- Complement System, Lipid Metabolism
抗原
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