Angiopoietin 1 Protein (ANGPT1) (AA 20-498)
Quick Overview for Angiopoietin 1 Protein (ANGPT1) (AA 20-498) (ABIN2816939)
抗原
See all Angiopoietin 1 (ANGPT1) 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 20-498
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序列
- Ser20 - Phe498, Accession # Q5HYA0
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产品特性
- Biological Activity: The ED50, as determined by inhibiting serum deprivation induced apoptosis in human HUVEC, is less than 50 ng/mL in the presence of a Mouse Anti-polyHistidine Monoclonal Antibody.
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过滤
- 0.2 μm filtered
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Angiopoietin 1 (ANGPT1) (AA 20-498) protein
ANGPT1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % by SDS - PAGE SDS
Angiopoietin 1 (ANGPT1) protein (Fc Tag)ANGPT1 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Angiopoietin 1 (ANGPT1) (AA 1-498) protein (GST tag)ANGPT1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 50 mM Tris-Citrate, pH 6.5, 500 mM NaCl
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储存条件
- -20 °C
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- Angiopoietin 1 (ANGPT1)
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别名
- ANGPT1
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背景
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Relevance: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:9204896}.
Synonyms: ANG-1, -
分子量
- 56.3 kDa
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UniProt
- Q15389
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途径
- RTK signaling, Glycosaminoglycan Metabolic Process
抗原
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