EPH Receptor A5 Protein (EPHA5)
-
- 抗原 See all EPH Receptor A5 (EPHA5) 蛋白
- EPH Receptor A5 (EPHA5)
- 蛋白类型
- Recombinant
-
宿主
- 小鼠, 大鼠
-
资源
- 大肠杆菌（E. Coli）
- 应用范围
- Western Blotting (WB), Positive Control (PC)
- 原理
- Purified Protein in ready-to-use SDS sample buffer.
- 纯化方法
- Purified Protein
- Top Product
- Discover our top product EPHA5 蛋白
-
EPH Receptor A5 (EPHA5) (AA 27-412) protein (His tag)
EPHA5 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A5 (EPHA5) (AA 26-573) protein (His tag)EPHA5 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A5 (EPHA5) (AA 25-572) protein (His tag)EPHA5 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A5 (EPHA5) (AA 662-948) (Active) protein (GST tag)EPHA5 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
EPH Receptor A5 (EPHA5) (AA 595-1037) (Active) protein (His-GST)EPHA5 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
EPH Receptor A5 (EPHA5) (AA 234-333) protein (GST tag)EPHA5 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor A5 (EPHA5) (AA 27-412) protein (His tag)Crystallography grade EPHA5 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
EPH Receptor A5 (EPHA5) (AA 25-573) protein (His tag)Crystallography grade EPHA5 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
EPH Receptor A5 (EPHA5) (AA 595-1037) protein (His tag)Crystallography grade EPHA5 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
EPH Receptor A5 (EPHA5) (AA 434-876) protein (His tag)Crystallography grade EPHA5 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
-
- 应用备注
- The sample is in ready-to-use buffer for application in SDS-PAGE and Western blotting.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- For 5 applications, volume varies from 100-200 μL in reduced SDS-PAGE sample buffer.
- 储存条件
- -20 °C
- 储存方法
- -20 °C for long term storage
-
- 抗原
- EPH Receptor A5 (EPHA5)
- 别名
- Eprhin Receptor A5 (EPHA5 产品)
- 别名
- CEK7 Protein, EHK-1 Protein, EHK1 Protein, EK7 Protein, HEK7 Protein, TYRO4 Protein, AI854630 Protein, AW125296 Protein, Cek7 Protein, Ehk1 Protein, Els1 Protein, Hek7 Protein, Rek7 Protein, bsk Protein, Els1. Protein, EPHA5 Protein, EPH receptor A5 Protein, Eph receptor A5 Protein, EPHA5 Protein, epha5 Protein, Epha5 Protein
- 背景
- The Ephrin receptors represent the largest group of Receptor Tyrosine Kinases, comprising of 14 members and divided in two subclasses (class A & B ephrin ligands) based on their abilities to bind and activate each other, and on sequence conservation. Ephrin-A (EFNA) class is anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) classes are trans-membrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrins interact with a variety of membrane receptors that respond to chemokines, neurotransmitters or growth factors. Eph receptors are involved in central nervous system function and development, and in the modulation of different types of nociception. Eph receptors and their ligands play important roles in the regulation of cancer cell migration and invasion and are key regulators of axon guidance. They function in a variety of signaling modes by transducing signals from the cell exterior to the interior through ligand-induced activation of their kinase domain. Ephrin A5, a member of the ephrin family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. Ephrin-A5 is highly expressed in the developing nervous system in several brain regions including the olfactory bulb, frontal cortex, striatum and hypothalamus. Ephrin-A5 acts as a guidance molecule regulating the trajectory of the ascending midbrain dopaminergic pathways. Ephrin- A5 expression is critical for proper development of central monoaminergic pathways and that its loss results in various neurodevelopmental abnormalities. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and mediate developmental events in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EphrinA5 possesses two alternative isoforms, large ephrinA5 isoform (ephrinA5L) and small ephrinA5 isoform (ephrinA5S). EphrinA5L is a putative tumor suppressor in several types of human cancers and ephrin A5S, acts as a tumor suppressor specifically in human hepatocellular carcinomas (HCC).The gene for EphA R5 is present on chromosome 5q21
- 分子量
- 124 kDa
- NCBI登录号
- NP_004430
- UniProt
- P54756
- 途径
- RTK signaling
-
