Thymic Stromal Lymphopoietin Protein (TSLP) (Transcript Variant 1)
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Quick Overview for Thymic Stromal Lymphopoietin Protein (TSLP) (Transcript Variant 1) (ABIN2734447)
抗原
See all Thymic Stromal Lymphopoietin (TSLP) 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- Transcript Variant 1
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特异性
- Optimal preservation of protein structure, post-translational modifications and functions.
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产品特性
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- Recombinant human TSLP (transcript variant 1) protein expressed in E. coli.
- Produced with end-sequenced ORF clone
- Tested for bioactivity.
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内毒素水平
- Less than 0.01 ng per μg protein as determined by the LAL method.
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Biological Activity Comment
- The ED50 is 1 - 5 ng/ml, corresponding to a specific activity of 0.2 - 1 x 10^6 units/mg, determined by the dose dependent stimulation of mouse BaF3-human IL-7a and human TSLPR cotransfectant cell proliferation.
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Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) protein (His-Avi Tag)
TSLP 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159), (R127A), (R130A) (Active) protein (Biotin,His-Avi Tag)TSLP 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159), (R127A), (R130A) protein (His-Avi Tag)TSLP 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) (Active) protein (Biotin,His-Avi Tag)TSLP 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) (Active) protein (His tag)TSLP 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Thymic Stromal Lymphopoietin (TSLP) (Active) protein (His tag)TSLP 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE. Active
Thymic Stromal Lymphopoietin (TSLP) (Active) protein (His tag)TSLP 宿主: Cynomolgus 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by reducing SDS-PAGE. Active
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) protein (Fc Tag)TSLP 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) (Active) protein (His tag)TSLP 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) (Active) protein (His tag,AVI tag,Biotin)TSLP 宿主: 人 宿主: HEK-293 Cells Recombinant >85 % as determined by SDS-PAGE. Active
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应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays -
限制
- 仅限研究用
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浓度
- > 50 μg/mL
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缓冲液
- 20 mM NaHPO4, pH 7.2, 0.15 M NaCl.
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储存条件
- -80 °C
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储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Thymic Stromal Lymphopoietin (TSLP)
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别名
- Tslp
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背景
- This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.
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分子量
- 15 kDa
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NCBI登录号
- NP_149024
抗原
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