PAK4 Protein (Transcript Variant 1)
Quick Overview for PAK4 Protein (Transcript Variant 1) (ABIN2728177)
抗原
See all PAK4 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- Transcript Variant 1
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特异性
- Optimal preservation of protein structure, post-translational modifications and functions.
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产品特性
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- Recombinant human PAK4 (transcript variant 1) protein expressed in E. coli.
- Produced with end-sequenced ORF clone
- Tested for bioactivity.
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内毒素水平
- <0.1 ng/μg of protein (<1EU/μg).
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Biological Activity Comment
- Specific activity was determined as 5,595 pmoles/min/μg, according to the Zlyte assay protocol
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P21-Activated Kinase 4 (PAK4) (AA 1-593) protein (His tag)
custom-made PAK4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
P21-Activated Kinase 4 (PAK4) (AA 1-591) protein (His tag)custom-made PAK4 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
P21-Activated Kinase 4 (PAK4) (AA 1-259) protein (His tag)PAK4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
P21-Activated Kinase 4 (PAK4) (AA 1-591) protein (His tag)PAK4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % by SDS - PAGE SDS
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应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- 25 mM Tris-HCl pH 8.0, 150 mM NaCl, 10 % glycerol, 5 mM DTT.
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储存条件
- -80 °C
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储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- PAK4 (P21-Activated Kinase 4 (PAK4))
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别名
- Pak4
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背景
- PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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分子量
- 33.3 kDa
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NCBI登录号
- NP_005875
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途径
- RTK signaling
抗原
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