KNG1 Protein (Transcript Variant 2)
Our Local Distributor
北京 101111
Quick Overview for KNG1 Protein (Transcript Variant 2) (ABIN2724258)
抗原
See all KNG1 蛋白蛋白类型
宿主
资源
应用范围
纯度
-
-
产品特性
- Transcript Variant 2
-
产品特性
-
- Recombinant human Kininogen-1 (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
-
内毒素水平
- < 0.1 EU per μg protein as determined by LAL test
-
-
Kininogen 1 (KNG1) (AA 19-380) protein (His-IF2DI Tag)
KNG1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Kininogen 1 (KNG1) (AA 1-427) protein (GST tag)KNG1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Kininogen 1 (KNG1) (AA 322-427) protein (GST tag)KNG1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Kininogen 1 (KNG1) (Active) protein (His tag)KNG1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
-
-
应用备注
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
限制
- 仅限研究用
-
-
-
缓冲液
- Lyophilized from a 0.2 μM filtered solution of 20 mM Hac-NaAC, 150 mM NaCl, pH 4.0. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
-
储存条件
- -80 °C
-
储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
-
- KNG1 (Kininogen 1 (KNG1))
-
别名
- Kininogen-1
-
背景
- (1) Kininogens are inhibitors of thiol proteases (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action) (5) LMW-kininogen inhibits the aggregation of thrombocytes (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. [UniProtKB/Swiss-Prot Function]
-
分子量
- 46.9 kDa
-
NCBI登录号
- NP_000884
-
途径
- ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process
抗原
-
