FURIN Protein (Myc-DYKDDDDK Tag)
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Quick Overview for FURIN Protein (Myc-DYKDDDDK Tag) (ABIN2721460)
抗原
See all FURIN 蛋白蛋白类型
宿主
资源
应用范围
纯度
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标记
- This FURIN protein is labelled with Myc-DYKDDDDK Tag.
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产品特性
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- Recombinant human Furin protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 28-794) protein (GST tag)
FURIN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 1-148) proteinFURIN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % pure SDS
Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 27-574) protein (His tag)FURIN 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 108-371) protein (His-IF2DI Tag)FURIN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
说明
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The tag is located at the C-terminal.
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限制
- 仅限研究用
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浓度
- 50 μg/mL
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缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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储存条件
- -80 °C
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储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))
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别名
- Furin
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背景
- This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.
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分子量
- 86.5 kDa
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NCBI登录号
- NP_002560
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途径
- Notch Signaling, Neurotrophin Signaling Pathway
抗原
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