IL4 Receptor Protein (Transcript Variant 1)
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北京 101111
Quick Overview for IL4 Receptor Protein (Transcript Variant 1) (ABIN2713396)
抗原
See all IL4 Receptor (IL4R) 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- Transcript Variant 1
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特异性
- Optimal preservation of protein structure, post-translational modifications and functions.
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产品特性
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- Recombinant human CD124 / IL4R (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Tested for bioactivity.
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内毒素水平
- Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
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Biological Activity Comment
- ED50 was determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells is less than or equal to 5.0 ng/ml (in the presence of 0.5 ng/ml of IL-4), corresponding to a specific activity of > 2 x 10^5 units/mg.
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Interleukin 4 Receptor (IL4R) (AA 24-232) protein (Fc Tag)
IL4R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 4 Receptor (IL4R) (AA 26-232) protein (His tag)IL4R 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 4 Receptor (IL4R) (AA 24-232) protein (His tag)IL4R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 4 Receptor (IL4R) (AA 26-232) protein (Fc Tag)IL4R 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 4 Receptor (IL4R) (AA 26-232) protein (mFc Tag)IL4R 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 4 Receptor (IL4R) (AA 26-232) protein (His tag)IL4R 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 4 Receptor (IL4R) (AA 26-232) (Active) protein (Fc Tag)IL4R 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 4 Receptor (IL4R) protein (His tag)IL4R 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 4 Receptor (IL4R) (Active) protein (His tag)IL4R 宿主: Cynomolgus 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Interleukin 4 Receptor (IL4R) protein (Fc Tag)IL4R 宿主: 小鼠 宿主: 人细胞 Recombinant > 90 % as determined by reducing SDS-PAGE.
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应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays -
限制
- 仅限研究用
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缓冲液
- Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
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注意事项
- Resuspend the protein in the desired concentration in proper buffer
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储存条件
- -80 °C
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储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
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别名
- Cd124,il4r
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背景
- This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
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分子量
- 24 kDa
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NCBI登录号
- NP_000409
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途径
- JAK/STAT Signaling, Positive Regulation of Immune Effector Process
抗原
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