Lamin A/C Protein (LMNA)
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Quick Overview for Lamin A/C Protein (LMNA) (ABIN2669331)
抗原
See all Lamin A/C (LMNA) 蛋白蛋白类型
宿主
资源
应用范围
纯度
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产品特性
- Recombinant human lamin A is a 645 amino acids protein with a molecular weight of 70 kDa.
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Lamin A/C (LMNA) (AA 1-664) protein (GST tag)
LMNA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Lamin A/C (LMNA) (AA 26-198) protein (His tag)LMNA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Lamin A/C (LMNA) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)LMNA 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Lamin A/C (LMNA) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)LMNA 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 20 mM phosphate buffer pH 7.0, 0.5M NaCl, 1 mM DTT, 1.5 mM EDTA, 20 % (v/v) glycerol
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储存条件
- -20 °C
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- Lamin A/C (LMNA)
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别名
- Lamin A
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背景
- Lamin A is a major component of the nuclear lamina, a dynamic meshwork located just under the nuclear envelope and it is encoded by lamin A/C gene (LMNA). Lamin A is synthesized as a longer precursor, prelamin A (code REP0038), that in vivo undergoes to serial post-translational modifications that lead to mature lamin A. Different mutations in the LMNA gene have been associated with different diseases that are collectively called laminophaties, including Emery-Dreifuss muscular dystrophy, familiar partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
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途径
- Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
抗原
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