IL-25 Protein (AA 33-177)
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Quick Overview for IL-25 Protein (AA 33-177) (ABIN2667478)
抗原
See all IL-25 (IL25) 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 33-177
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内毒素水平
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Less than 0.1 ng per μg of protein.
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Interleukin 25 (IL25) (AA 33-177) protein (His-Avi Tag,Biotin)
IL25 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 25 (IL25) (Active) proteinIL25 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Interleukin 25 (IL25) (AA 33-177) protein (Fc Tag)IL25 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 25 (IL25) (AA 33-177) protein (His tag)IL25 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 25 (IL25) (AA 17-169) protein (His tag)IL25 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 25 (IL25) (AA 1-177) protein (GST tag)IL25 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Interleukin 25 (IL25) (Active) protein (Fc Tag)IL25 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active
Interleukin 25 (IL25) proteinIL25 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
Interleukin 25 (IL25) proteinIL25 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
Interleukin 25 (IL25) proteinIL25 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Biological activity: Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10 - 100 ng.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
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缓冲液
- Lyophilized, carrier-free.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Unopened vial can be stored at -20°C or -70°C.
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- IL-25 (IL25) (Interleukin 25 (IL25))
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别名
- IL-17E
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背景
- IL-17E, also known as IL-25, shares the least structural homology with other IL-17 family members and is also functionally distinct from other IL-17 familiy members. IL-17E is primarily involved in type 2 immune response. IL-17E can induce Th2 cytokines, including IL-4, IL-5, IL-9 and IL-13, in multiple tissues. IL-17E can also inhibit pro-inflammatory Th1 and Th17 cytokine response. It has been well established that IL-17E plays an important role in allergy and asthma. Blocking IL-25 has been a therapeutic option. IL-25 is also required for protection against gastrointestinal helminth infections. IL-17E-deficient mice exihibit impaired Th2 immune response. Exclusion of helminth parasites was delayed in IL-17E-deficient mice. Recently, the potential neuroprotective effect of IL-17E is also being explored. IL-17E can regulate the development of autoimmune inflammation mediated by IL-17-prodcuing T cells. IL-17E-deficient mice are highly susceptible to experimential autoimmune encephalomyelitis. Interestingly, in vivo antitumor activity of IL-17E has also been reported.
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分子量
- The 145 amino acid recombinant protein has a predicted molecular mass of approximately 17 kDa. Recombinant human IL-17 is a disulfide-linked homodimer (~34 kDa). The predicted N-terminal amino acid is Met.
抗原
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