FLT3LG Protein (AA 27-181)
Quick Overview for FLT3LG Protein (AA 27-181) (ABIN2667412)
抗原
See all FLT3LG 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 27-181
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内毒素水平
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Less than 0.1 ng per μg of protein.
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Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-185) protein (Fc Tag)
FLT3LG 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-185) protein (His tag)FLT3LG 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-189) protein (Fc Tag)FLT3LG 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-185) protein (mFc-His Tag)FLT3LG 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-185) protein (His tag)FLT3LG 宿主: 人 宿主: Hi-5 Cells Recombinant >90 % as determined by SDS-PAGE.
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) protein (His tag)FLT3LG 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 28-189) protein (His tag)FLT3LG 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-181) protein (His-IF2DI Tag)FLT3LG 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 1-235) protein (GST tag)FLT3LG 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) proteinAnimal-Free FLT3LG 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 98,00% SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Biological activity: ED50 ≤1.0 ng/ml, corresponding to a specific activity of ≥ 1.0 x 106 units/mg, as measured by its ability to stimulate the proliferation of human AML5 cells in a dose dependent manner.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
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缓冲液
- Lyophilized, carrier-free.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Unopened vial can be stored at -20°C or -70°C.
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- FLT3LG (Fms-Related tyrosine Kinase 3 Ligand (FLT3LG))
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别名
- Flt-3 Ligand
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背景
- Fms-like tyrosine kinase 3 ligand is a hematopoietic cytokine structurally similar to stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). Flt-3 ligand synergizes with other growth factors, such as interleukin-7 (IL-7) and CSFs, to promote proliferation and differentiation of early hematopoietic cells. In addition, Flt-3 ligand is involved in the commitment and expansion of dendritic cells as well as stimulating B cells, T cells, and NK cells. Both soluble form and membrane-bound forms of Flt-3 ligand are able to stimulate the cells expressing receptor tyrosine kinases Flt-3, transducing signals through the ERK and PI3K pathway. Flt-3 ligand is the only known ligand for Flt-3. Flt-3 and Flt-3 ligand have been implicated to participate in leukemogenesis, since the constitutively activated mutants of Flt-3 were found to be associated with the acute myeloid leukemia (AML).
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分子量
- The 155 amino acid recombinant protein has a predicted molecular mass of approximately 17.6 kDa. The predicted N-terminal amino acid is Thr.
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途径
- RTK signaling
抗原
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